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What Exactly Is Redox Signaling Procedure And What's Its Importance To Our Body
Redox Signaling refers to the procedure in which free radicals, reactive oxygen species and other electronically activated radicals act as messengers in the biological system. It's basically the process that shows how cells in our body respond to free radicals and oxidants. Redox signaling is a consistent and important process, through which human cells connect with each other and carry out vital body functions.
What are Redox Signaling Molecules?
There are two kinds of Signaling molecules - "activator" and "communicator". These two play the role of messengers and are accountable for the connection between cells throughout our body. Also called Signaling molecules, they switch on the body's antioxidant compounds - Glutathione, SOD and Catalase.
In simpler terms, Redox signaling molecules are elements that are produced naturally within each cell of the body. When the cells are required to perform many functions, they generate two types of signaling molecules.
The initial set of "activator" molecules set off the antioxidants stored in the body. Antioxidants are very effective in fighting off the damage caused by free radicals and oxidative stress; on the other hand they cannot function unless activated by the signaling molecules. Therefore you require the Redox signaling 'activator' molecules to get the antioxidants to work.
The 2nd set of "communicator" molecules is accountable for enabling correct communication between the cells of the body, making sure optimum performance of the immune system and protecting the body against outside stimuli such as harmful bacteria, viruses etc. The millions of cells in our body are able to properly function and communicate because of the Redox signaling molecules.
Why is Redox signaling so important?
Both the external and internal factors such as toxic chemicals, stress poor nutrition, bacterial infections etc affect our health in an undesirable way. This causes significant cellular damage and a reduction in Redox signaling molecules. With out an adequate supply of Redox signaling molecules the antioxidants and immune system are unable to function effectively, contributing to a vast range of health ailments.
Researchers and researchers worldwide have been conducting several researches on the Redox signaling molecules to discover more about their structure, effect and function with respect to human health. Let's take a look at many of the popular studies on this subject:
White, Blue-eyed Cats are Deaf
Charles Darwin, the father of evolution had pointed out "white cats with blue eyes are almost deaf". He proposed that developmental issues with the nervous system may be the cause of deafness in the white, blue-eyed cats. But scientists think it has something to do with the Redox signaling process, as Central nervous system growth is a messenger-mediated process and so is the melanin synthesis.
Therefore an imbalance in the Redox signaling process leads to improper melanin synthesis (giving the cat its white color) and results in defective intra-cellular communication (causing hearing impairment).
Study by Hoffer and Osmond
The very first instance of Redox processes being engaged in cell signaling was given by Hoffer and Osmond. According to the Adrenochrome hypothesis, "psychoactive oxidative items of catecholamines (adrenochromes) play a role in schizophrenia and other neuropsychiatric diseases". Although the proposed hypothesis still remains in question, the fact that messenger-mediated oxidative stress can lead to neuropsychiatric diseases, has been proven correct.
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